Antiplasmodial Activities and Cytotoxic Effects of Aqueous Extracts and Sesquiterpene Lactones from Neurolaena lobata*

Guido François; Claus M. Passreiter; Herman J. Woerdenbag; Marleen Van Looveren

doi:10.1055/s-2006-957833

Planta Medica, Table of Contents

Planta Med 1996; 62(2): 126-129
DOI: 10.1055/s-2006-957833

Papers

Antiplasmodial Activities and Cytotoxic Effects of Aqueous Extracts and Sesquiterpene Lactones from *Neurolaena lobata**

Guido François¹ , Claus M. Passreiter² , Herman J. Woerdenbag³ , Marleen Van Looveren¹

¹Laboratorium voor Protozoölogie, Prins Leopold Instituut voor Tropische Geneeskunde, Nationalestraat 155, B-2000 Antwerpen, Belgium
²Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany
³Department of Pharmaceutical Biology, University Centre for Pharmacy, University of Groningen, Antonius Deusinglaan 2, NL-9713 AW Groningen, The Netherlands

* Partly presented at the 2nd European Congress on Pharmaceutical Sciences, Berlin, 1994.

Abstract

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Abstract

Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.

Key words

Neurolaena lobata (L.) R. Br. - Asteraceae - cytotoxicity - malaria - Plasmodium falciparum - sesquiterpene lactones

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